Hello Bioinformatics lovers,

Happy New Year! It is 2025 already. That means it is time to set up your goals.

To achieve your goals, this is the framework:

• Eliminate the distractions,
• take actions,
• find an efficient way to do it,
• maintain the efficiency

So, you need to get rid of the distractions and take action Now!

For example, I have told you many times to build yourself a website to showcase your bioinformatics portfolio.

How many of you have done that? (Thanks to those who sent me your websites, that makes my day!)

How about making that one of your new year's goals?

Here is the template if you use the github page, and the template for Rmarkdown/Quarto.

Block a day, and you prioritize doing only this task. NO OTHER THINGS!

Every goal has a price tag. You will need to sacrifice.

Do not have time? Cutoff Netflix and YouTube (not my Chatomics channel :))

Do not have resources? That's an excuse.

Take a look at https://github.com/harvardinformatics/learning-bioinformatics-at-home (I started the repo 5 years ago).

The free resources are abundant online, it is the desire to learn that is rare.

It takes time to gain proficiency in bioinformatics.

12 years after I typed my first "Hello world", I can finally say I started to have a mastery of bioinformatics.

Play the long-term game. Elon started SpaceX 22 years ago!

The goal usually takes longer. Set up the time to finish the goal, and then x 3.

Remember, volume negates luck. Practice a lot!

I have been writing the end-to-end tutorial to replicate Figure 1 in this paper during the holidays.

I will share it with you in my next newsletter. Stay tuned!

Happy Learning!

Tommy aka Crazyhottommy

PS: I made this video for K-means clustering using gene expression data.

scripts to follow https://github.com/crazyhottommy/compbio_tutorials/blob/main/scripts/R_tips_19_kmeans_clustering.Rmd​

PPS:

If you want to learn Bioinformatics, there are other ways that I can help:

1. My free YouTube Chatomics channel, make sure you subscribe to it.
2. I have many resources collected on my github here.
3. I have been writing blog posts for over 10 years https://divingintogeneticsandgenomics.com/​

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Stay awesome!